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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

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Published on: July 28, 2013

Longitudinal changes in diffusion tensor-based quantitative MRI in multiple sclerosis.

D M Harrison1, B S Caffo, N Shiee

  • 1Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. dharri90@jhmi.edu

Neurology
|January 12, 2011
PubMed
Summary
This summary is machine-generated.

Quantitative MRI reliably tracks changes in multiple sclerosis (MS) over time. This study shows these MRI measures are feasible for small clinical trials in MS patients.

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Area of Science:

  • Neuroimaging
  • Neurology
  • Medical Imaging

Background:

  • Multiple sclerosis (MS) is a chronic neurological disease characterized by demyelination and axonal damage.
  • Quantitative MRI offers potential for monitoring disease progression and treatment efficacy in MS.

Purpose of the Study:

  • To assess longitudinal changes in whole-brain and tract-specific MRI measures in individuals with MS.
  • To determine the feasibility of using these quantitative MRI techniques in clinical trials for MS.

Main Methods:

  • 78 MS patients underwent 3 MRI scans over 2 years.
  • Diffusion tensor imaging (DTI) indices, magnetization transfer ratio (MTR), and T2 relaxation time were analyzed in specific brain regions and tracts.
  • Linear mixed-effect models were used to estimate annualized rates of change and determine sample sizes for clinical trials.

Main Results:

  • Significant longitudinal changes were observed in DTI indices (fractional anisotropy, diffusivity) and MTR across various brain regions, particularly the corpus callosum.
  • MTR showed accelerated decline in progressive MS compared to relapsing-remitting MS.
  • Power analysis indicated feasible sample sizes (around 40 participants per arm) for 1-2 year clinical trials.

Conclusions:

  • Longitudinal quantification of whole-brain and tract-specific DTI indices and MTR is reliable in MS.
  • These quantitative MRI outcomes are feasible for use in small-scale clinical trials for multiple sclerosis.