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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Hyperglycemia01:29

Hyperglycemia

Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

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Related Experiment Video

Updated: Jun 5, 2026

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

[Changes in glucose tolerance in elderly].

Israel Lerman-Garber1, Mariana Rosales-Calderón

  • 1Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, México, DF. israellerman@gmail.com

Revista De Investigacion Clinica; Organo Del Hospital De Enfermedades De La Nutricion
|January 13, 2011
PubMed
Summary

As people age, glucose tolerance often declines, increasing the risk of type 2 diabetes. Lifestyle changes are key to preventing diabetes in older adults.

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A Method for Manipulating Blood Glucose and Measuring Resulting Changes in Cognitive Accessibility of Target Stimuli
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A Method for Manipulating Blood Glucose and Measuring Resulting Changes in Cognitive Accessibility of Target Stimuli

Published on: August 12, 2016

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Last Updated: Jun 5, 2026

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

A Method for Manipulating Blood Glucose and Measuring Resulting Changes in Cognitive Accessibility of Target Stimuli
08:01

A Method for Manipulating Blood Glucose and Measuring Resulting Changes in Cognitive Accessibility of Target Stimuli

Published on: August 12, 2016

Area of Science:

  • Gerontology
  • Metabolic Health
  • Endocrinology

Background:

  • Glucose tolerance naturally declines with aging, leading to a high prevalence of type 2 diabetes and impaired glucose tolerance in the elderly.
  • Age-related glucose intolerance is multifactorial, involving increased visceral adiposity, reduced physical activity, medications, comorbidities, and diminished insulin secretion/sensitivity.
  • The precise impact of aging on glucose metabolism remains a subject of ongoing research and debate.

Purpose of the Study:

  • To explore the complex factors contributing to age-related glucose intolerance.
  • To highlight the prevalence and specific characteristics of diabetes in older populations.
  • To emphasize the role of lifestyle modifications in preventing diabetes in the elderly.

Main Methods:

  • Review of existing literature on aging and glucose metabolism.
  • Analysis of epidemiological data concerning glucose intolerance in older adults in Mexico.
  • Examination of clinical characteristics of elderly patients diagnosed with diabetes.

Main Results:

  • Glucose intolerance affects 15-20% of Mexicans over 60, elevating risks for diabetes and cardiovascular disease.
  • Elderly patients with diabetes often present with lower obesity rates, more significant beta-cell dysfunction, and potential hyperosmolar states.
  • Lifestyle interventions demonstrate significant efficacy in preventing diabetes onset within this demographic.

Conclusions:

  • Age-related decline in glucose tolerance is a significant public health concern, particularly in populations like Mexico.
  • Understanding the unique clinical profiles of diabetes in older adults is crucial for effective management.
  • Proactive lifestyle modifications represent a vital strategy for mitigating diabetes risk in aging populations.