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Updated: Jun 5, 2026

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Esthesioneuroblastoma: a case report.

R C Shukla1, P K Singh, S Senthil

  • 1Department of Radiodiagnosis and Imaging, BHU, Varanasi, India.

Nepal Medical College Journal : NMCJ
|January 13, 2011
PubMed
Summary
This summary is machine-generated.

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Esthesioneuroblastoma, a rare neuroectodermal tumor, presents varied biological activity. Early detection and multimodal treatment, including surgery, radiation, and chemotherapy, are crucial for managing this sinonasal malignancy.

Area of Science:

  • Oncology
  • Otorhinolaryngology
  • Neurosurgery

Background:

  • Esthesioneuroblastoma (olfactory neuroblastoma) is a rare neuroectodermal tumor with unpredictable biological behavior.
  • Treatment typically involves surgery, radiation, and chemotherapy, tailored to disease stage and patient factors.
  • Common symptoms include nasal obstruction, epistaxis, and olfactory dysfunction.

Observation:

  • A case of esthesioneuroblastoma presented with bilateral nasal obstruction, epistaxis, right proptosis, decreased visual acuity, and anosmia.
  • Imaging revealed a large, destructive mass involving the nasal cavity, paranasal sinuses, and extending to the orbit and anterior cranial fossa.
  • Histopathological analysis confirmed neuroblastoma.

Findings:

  • The modified Kadish staging system, lymph node status, treatment modality, and patient age are significant prognostic indicators.

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  • Multimodal therapy including radiotherapy and chemotherapy was administered to the patient.
  • Despite extensive bony destruction, excellent outcomes are achievable with appropriate management.

    • Implications:

    • Esthesioneuroblastoma requires long-term follow-up due to the potential for late recurrence.
    • Surgical salvage remains a viable option for recurrent sinonasal malignancies, distinguishing it from other cancers.
    • This case highlights the importance of comprehensive evaluation and tailored treatment strategies for esthesioneuroblastoma.