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Related Experiment Video

Updated: Jun 5, 2026

Coronary Artery Ligation and Intramyocardial Injection in a Murine Model of Infarction
07:41

Coronary Artery Ligation and Intramyocardial Injection in a Murine Model of Infarction

Published on: June 7, 2011

Tissue engineering for post-myocardial infarction ventricular remodeling.

T M Kolettis1, A Vilaeti, K Dimos

  • 1Department of Cardiology, University of Ioannina, 1 Stavrou Niarxou Avenue, 45110 Ioannina, Greece. thkolet@cc.uoi.gr

Mini Reviews in Medicinal Chemistry
|January 13, 2011
PubMed
Summary

Myocardial tissue engineering uses biomaterial scaffolds to regenerate heart tissue after myocardial infarction. While promising, further research is needed before clinical human application.

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A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.

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Related Experiment Videos

Last Updated: Jun 5, 2026

Coronary Artery Ligation and Intramyocardial Injection in a Murine Model of Infarction
07:41

Coronary Artery Ligation and Intramyocardial Injection in a Murine Model of Infarction

Published on: June 7, 2011

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets
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A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.
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A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.

Published on: June 14, 2015

Area of Science:

  • Biomaterials science
  • Regenerative medicine
  • Cardiovascular research

Background:

  • Myocardial infarction leads to necrotic myocardium, requiring regeneration strategies.
  • Biomaterial scaffolds offer mechanical support and delivery for cardiac repair.

Purpose of the Study:

  • To review the role of biomaterial scaffolds in myocardial tissue engineering.
  • To discuss their potential for treating myocardial infarction.

Main Methods:

  • Literature review of experimental studies on myocardial tissue engineering.
  • Analysis of biomaterial applications in cardiac regeneration.

Main Results:

  • Biomaterial scaffolds support infarct areas and deliver cells/growth factors.
  • Experimental studies show promising results for cardiac repair.

Conclusions:

  • Myocardial tissue engineering with biomaterials is a promising approach for myocardial infarction.
  • Significant challenges remain for successful translation to human clinical use.