Related Experiment Video
Updated: Jun 5, 2026
09:19
NMR-Based Fragment Screening in a Minimum Sample but Maximum Automation Mode
Published on: June 4, 2021
NMR applications for identifying β-TrCP protein-ligand interactions
J Pons1, V Tanchou, J-P Girault
1Université Paris Descartes, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques (UMR 8601 CNRS), 45 rue des Saint-Pères, 75006 Paris, France.
Mini Reviews in Medicinal Chemistry
|January 13, 2011
Abstract:
In the absence of crystallographic data, NMR has emerged as the best way to define protein-ligand interactions. Using NMR experiments based on magnetization transfer, one can sort bound from unbound molecules, estimate the dissociation constant, identify contacts implied in the binding, characterize the structure of the bound ligand and conduct ligand competition assays.
