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Related Concept Videos

Amyloid Fibrils

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...

Amyloid Fibrils

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...

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Related Experiment Video

Updated: Jun 5, 2026

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

In vivo human amyloid imaging.

J Sojkova¹, S M Resnick

¹Laboratory of Personality and Cognition, NIH Biomedical Research Center, National Institute on Aging, IRP, Baltimore, MD 21224, USA.

Current Alzheimer Research

|January 13, 2011

Summary

Positron emission tomography (PET) imaging with Pittsburgh compound B (PiB) detects fibrillar beta-amyloid (Aβ) in vivo. This technique advances understanding of Aβ deposition in aging, cognitive decline, and clinical trials.

Area of Science:

Neuroimaging
Neuropathology
Gerontology

Background:

Fibrillar beta-amyloid (Aβ) deposition is a hallmark of Alzheimer's disease.
Positron emission tomography (PET) imaging agents like Pittsburgh compound B (PiB) enable in vivo detection of Aβ.
Understanding Aβ deposition is crucial for studying cognitive impairment and aging.

Purpose of the Study:

To review the advancements in in vivo amyloid imaging using PiB PET.
To highlight the role of PiB PET in quantifying Aβ deposition across different cognitive states.
To discuss the implications of PiB PET findings for understanding neurobiological events leading to cognitive decline and for clinical trial applications.

Main Methods:

Utilizes Pittsburgh compound B (PiB) as a PET imaging tracer.

More Related Videos

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging

Published on: October 20, 2017

Related Experiment Videos

Last Updated: Jun 5, 2026

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging

Published on: October 20, 2017

Quantifies fibrillar Aβ deposition in the brain in vivo.

Correlates Aβ burden with cognitive status, genotype, and other biomarkers.

Main Results:

PiB PET allows quantification of Aβ deposition in mild cognitive impairment and Alzheimer's disease.
Aβ deposition is observed even in cognitively unimpaired older adults.
Studies have reported longitudinal changes in Aβ burden and its relationship with cognition.

Conclusions:

In vivo amyloid imaging with PiB PET has significantly advanced the understanding of Aβ's role in aging and cognitive decline.
PiB PET provides valuable tools for patient selection and therapeutic monitoring in clinical trials.
Further correlation with biopsy/postmortem data will enhance quantitative interpretation of PiB PET findings.