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Updated: Feb 25, 2026
Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes
Published on: December 20, 2019
Chromosome 17 in FTLD: from MAPT tau to progranulin and back
A Alberici1, M Cosseddu, A Padovani
1Clinic of Neurology, Spedali Civili, University of Brescia, P.zzale Spedali Civili, Brescia, Italy. antoalberici@yahoo.it
Abstract:
Frontotemporal Lobar degeneration (FTLD) is one of the most important neurodegenerative conditions, affecting in the presenium, but more recently recognized also in aged population. The strong genetic background, along with autopsy determinations prompted the identification of the two major genes associated to the disease: MAPT gene, and Progranulin (PGRN) gene. In this review, we highlighted the milestones of these discoveries, and their implication for the development of future therapeuthical approaches.
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