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Related Concept Videos

Types of Step-Growth Polymers: Polyesters01:20

Types of Step-Growth Polymers: Polyesters

The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the polymer...
Bioplastics01:27

Bioplastics

Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...
Polymer Classification: Architecture01:14

Polymer Classification: Architecture

Polymers are classified as linear or branched on the basis of their chain architecture. The polymer chains in linear polymers have a long chain-like structure with minimal to no branching at all. Even if a polymer features large substituent groups on the monomer, which appear as branches to the skeleton, it is not considered a branched polymer. A branched polymer contains secondary polymer chains that arise from the main polymer chain. The branching occurs when the polymer growth shifts from...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Classification and Mechanical Properties of Synthetic Polymers01:28

Classification and Mechanical Properties of Synthetic Polymers

Synthetic polymers are classified as elastomers, fibers, or plastics based on their crystallinity. Crystallinity, the degree of long-range order in the solid state, influences the mechanical properties (stretching or contracting) of elastomers. Elastomers are flexible polymers that can expand or contract easily upon the application of an external force. They have numerous crosslinks that pull them back into their original shape when stress is removed. Silicones, for instance, are highly elastic...
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Polymer Classification: Stereospecificity

Polymerization generates chiral centers along the entire backbone of a polymer chain. Accordingly, the stereochemistry of the substituent group has a significant effect on polymer properties. Polymers formed from monosubstituted alkene monomers feature chiral carbons at every alternate position in the polymer backbone. Relative to the predominant orientation of substituents at the adjacent chiral carbons, the polymer can exist in three different configurations: isotactic, syndiotactic, and...

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Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
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Published on: August 28, 2015

Functional aliphatic polyesters for biomedical and pharmaceutical applications.

Hajar Seyednejad1, Amir H Ghassemi, Cornelus F van Nostrum

  • 1Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, P.O. Box 80082, 3508 TB Utrecht, The Netherlands.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|January 13, 2011
PubMed
Summary
This summary is machine-generated.

Functional aliphatic polyesters offer tunable properties for drug delivery and tissue engineering. Recent synthesis trends and applications in protein delivery are reviewed.

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Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Biomedical Engineering

Background:

  • Functional aliphatic polyesters are biodegradable polymers with tunable physico-chemical properties.
  • They offer advantages over traditional polyesters (e.g., PLLA, PLGA, PCL) in applications like drug delivery and tissue engineering.
  • Recent advancements focus on synthesizing these polymers via ring-opening polymerization (ROP) of cyclic esters.

Purpose of the Study:

  • To review recent trends in the synthesis of functional aliphatic polyesters.
  • To highlight their applications in protein delivery and tissue engineering.

Main Methods:

  • Review of recent literature on polyester synthesis and applications.
  • Focus on ring-opening polymerization (ROP) techniques.
  • Analysis of functional monomer homopolymerization and co-polymerization.

Main Results:

  • Numerous functional aliphatic polyesters have been synthesized through various polymerization methods.
  • These materials demonstrate significant potential for controlled drug delivery systems.
  • Their application as scaffolds in tissue engineering is expanding.

Conclusions:

  • Functional aliphatic polyesters represent a versatile class of biodegradable materials.
  • Advancements in synthesis, particularly ROP, enable tailored material properties.
  • These polymers are promising for sophisticated biomedical applications, including protein delivery and regenerative medicine.