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The attributable burden of hypertension: focus on CKD

Kenneth A Jamerson1, Raymond R Townsend

  • 1University of Michigan Medical Center, Ann Arbor, MI; and Renal Division, University of Pennsylvania, Philadelphia, PA 48106, USA. jamerson@umich.edu

Advances in Chronic Kidney Disease
|January 13, 2011
PubMed

Insights

High blood pressure (hypertension) significantly contributes to kidney damage and failure. This overview explores the epidemiologic and nephrologic links between hypertension and kidney disease progression.

Area of Science:

  • Nephrology
  • Cardiology
  • Epidemiology

Background:

  • Hypertension is a major global risk factor for cardiovascular and kidney disease.
  • The specific impact of elevated blood pressure on kidney disease development and progression is underestimated.
  • Kidneys are uniquely affected by hypertension, suffering damage while also potentially sustaining the condition.

Purpose of the Study:

  • To provide a nephrologic perspective on hypertension.
  • To discuss the epidemiologic links between high blood pressure and kidney damage.
  • To explore known and speculative mechanisms connecting hypertension to kidney disease.

Main Methods:

  • Literature review and synthesis.
  • Epidemiologic data analysis (implied).
  • Discussion of pathophysiologic mechanisms.

Main Results:

  • Elevated blood pressure is a significant, though often underappreciated, contributor to kidney disease.
  • The kidney's dual role in suffering damage and sustaining hypertension is highlighted.
  • Multiple mechanisms link hypertension to kidney pathology.

Conclusions:

  • Understanding the nephrologic impact of hypertension is crucial for preventing kidney disease.
  • Further research into the mechanisms linking hypertension and kidney damage is warranted.
  • Hypertension management is key to preserving kidney function.

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