Related Experiment Video
Updated: Jun 5, 2026
Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
Published on: July 25, 2020
Successful treatment of metastatic choriocarcinoma after DMP 840
C B Pratt1, B N Rao, C F Stewart
1Department of Hematology/Oncology, St. Jude Children's Research Hospital, USA; Departments of Pediatrics, Surgery, Pharmacy and Pathology, University of Tennessee Memphis, College of Medicine, Memphis, Tennessee, USA.
Abstract:
A 17-year-old male with retroperitoneal choriocarcinoma metastatic disease in the lungs has had shrinking of pulmonary metastases and primary tumor with four treatment courses of DMP 840. β-HCG appeared normal prior to resection of the necrotic primary tumor and a single remaining pulmonary metastasis, which was also necrotic. The patient remains free of tumor recurrence of 8 months following surgery. Further evaluation of DMP 840 in patients with germ cell tumors is indicated.