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Aldose reductase inhibitors.

W R Kirchain1, M S Rendell

  • 1Philadelphia College of Pharmacy and Science, Pennsylvania 19104-4495.

Pharmacotherapy
|January 1, 1990
PubMed
Summary

Aldose reductase inhibitors show promise for treating diabetic complications by targeting sorbitol production. However, current methods for proving their clinical effectiveness may need improvement.

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Area of Science:

  • Biochemistry
  • Endocrinology
  • Pharmacology

Background:

  • Current diabetes management focuses on blood sugar control and treating complications like neuropathy and retinopathy.
  • These approaches slow disease progression but do not address the root cause of diabetic complications.
  • Aldose reductase inhibitors are being explored as a novel therapeutic strategy.

Purpose of the Study:

  • To investigate the potential of aldose reductase inhibitors in managing diabetic complications.
  • To evaluate the role of sorbitol production in the development of these complications.

Main Methods:

  • Review of animal models demonstrating the link between sorbitol production and diabetic complications.
  • Analysis of human studies assessing the efficacy of aldose reductase inhibitors.
  • Examination of the enzyme aldose reductase's function in reducing glucose to sorbitol.

Main Results:

  • Evidence suggests aldose reductase inhibitors may offer significant relief for specific diabetic complications.
  • Animal studies indicate a correlation between sorbitol production and the onset of diabetic complications.
  • Human studies are exploring the therapeutic potential of these inhibitors.

Conclusions:

  • Aldose reductase inhibitors show potential for alleviating certain diabetic complications.
  • The existing methodologies for demonstrating the clinical efficacy of these drugs may be insufficient.

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