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Bireticulol, a bioactive isocoumarin dimer from Streptomyces sp. BCC24731
Chollaratt Boonlarppradab1, Chanwit Suriyachadkun, Sumalee Suphothina
1National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Klong 1, Klong Luang, Pathumthani, Thailand. chollaratt.boo@biotec.or.th
Abstract:
A new dimeric isocoumarin, bireticulol, was isolated from the terrestrial Streptomyces sp. and characterized as a 5-5' dimer of reticulol. In addition, reticulol and 8-hydroxy-6,7-dimethoxy-3-methyl isocoumarin, together with other known polyketides piericidin A, 2'-(2-hydroxyphenyl)-2,4'-bibenzoxazole-4-carboxylic acid methyl ester (UK-1) and 3-benzyl-4-hydroxy-5-methyldihydrofuran-2-one were also obtained. Bireticulol exhibited cytotoxic effects against KB (human epidermoid carcinoma, ATCC CCL-17) and NCI-H187 (human small cell lung cancer, ATCC CRL-5804) cell lines with IC(50) values of 24.4 and 8.31 μg ml(-1), respectively.
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