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Clinical Trials

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...

Clinical Trials: Overview

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...

Preclinical Development: Overview

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...

Clinically Relevant Drug Product Specifications: Methods of Establishment

Clinically Relevant Drug Product Specifications: Methods of Establishment

Product specifications define the acceptable quality of a pharmaceutical product by ensuring identity, purity, potency, and strength. These specifications serve as benchmarks during development, manufacturing, and post-approval quality control. Clinically relevant specifications are particularly important because they directly relate to a drug's safety and efficacy in clinical use.Dissolution studies are critical biopharmaceutic tools that link in vitro behavior to in vivo performance. They...

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...

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Updated: Jun 5, 2026

In Silico Clinical Trials for Cardiovascular Disease

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

Gateways to clinical trials.

A Tomillero¹, M A Moral

¹Thomson Reuters, Barcelona, Spain. scientific.prousjournals@thomsonreuters.com.

Methods and Findings in Experimental and Clinical Pharmacology

|January 13, 2011

Summary

This summary is machine-generated.

This guide summarizes recent clinical trials across various therapeutic areas, including oncology, immunology, and infectious diseases. It provides an overview of ongoing research and drug development, aiding researchers and clinicians in staying updated on the latest advancements.

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Area of Science:

Pharmaceuticals and Drug Development
Clinical Research
Medical Science

Context:

Gateways to Clinical Trials provides a comprehensive overview of recent clinical trials.
Data is sourced from Thomson Reuters Integrity, a leading drug discovery and development portal.
This issue highlights a wide array of drugs and therapeutic areas.

Purpose:

To offer a consolidated guide to the latest clinical trials in current literature and congresses.
To facilitate access to information on emerging drugs and treatment modalities.
To support researchers, clinicians, and industry professionals in their work.

Summary:

The guide details clinical trials for numerous drugs including Abatacept, Adalimumab, Aripiprazole, Bevacizumab, Bortezomib, and Imatinib mesylate.
It covers investigational drugs and therapies across diverse fields such as oncology, autoimmune diseases, and infectious diseases.
The compilation includes information on novel drug delivery systems like eluting stents and advanced vaccine technologies.

Impact:

Enhances awareness of ongoing clinical research and drug development pipelines.
Aids in identifying potential collaborations and research opportunities.
Supports evidence-based decision-making in clinical practice and pharmaceutical strategy.