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Related Experiment Video

Updated: Jun 5, 2026

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
12:24

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

Building a comprehensive genomic program for hepatocellular carcinoma.

Theresa R Harring1, Jacfranz J Guiteau, N Thao T Nguyen

  • 1Michael E. DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Jewish Bldg #404D, Houston, TX 77030, USA.

World Journal of Surgery
|January 13, 2011
PubMed
Summary

Researchers are analyzing the genomics of hepatocellular carcinoma (HCC) to develop new genetic therapies. This study aims to improve treatment outcomes for liver cancer patients by defining novel therapeutic strategies.

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Development and Optimization of A Human Hepatocellular Carcinoma Patient-Derived Organoid Model for Potential Target Identification and Drug Discovery

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Last Updated: Jun 5, 2026

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
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Published on: September 30, 2021

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Development and Optimization of A Human Hepatocellular Carcinoma Patient-Derived Organoid Model for Potential Target Identification and Drug Discovery
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Development and Optimization of A Human Hepatocellular Carcinoma Patient-Derived Organoid Model for Potential Target Identification and Drug Discovery

Published on: August 18, 2023

Area of Science:

  • Oncology
  • Genomics
  • Hepatology

Background:

  • Hepatocellular carcinoma (HCC) is a leading cause of cancer death globally.
  • Current treatments for advanced HCC offer poor outcomes.
  • Research focuses on understanding HCC genomics for improved therapies.

Purpose of the Study:

  • To elucidate the genomics of HCC.
  • To identify novel genetic therapeutic strategies for HCC.
  • To establish a framework for genomic analysis in personalized medicine.

Main Methods:

  • Specimen biobanking protocol established.
  • Genomic analysis techniques employed: whole genome sequencing, whole exome sequencing, gene-specific analysis, gene expression, and epigenetic analysis.

Main Results:

  • Whole genome sequencing completed on 2 samples.
  • Whole exome sequencing completed on 47 samples.
  • Gene-specific analysis completed on 94 samples, with gene expression and epigenetic analysis on fewer samples.

Conclusions:

  • Results aim to define novel genetic therapeutic strategies for HCC.
  • The study seeks to improve patient and graft survival rates.
  • A framework for comprehensive genomic analysis is proposed for broader application.