Drosophila as a model organism for the study of neuropsychiatric disorders

The fruitfly Drosophila offers a model system in which powerful genetic tools can be applied to understanding the neurobiological bases of a range of complex behaviors. The Drosophila and human lineages diverged several hundred million years ago, and despite their obvious differences, flies and humans share many fundamental cellular and neurobiological processes. The similarities include fundamental mechanisms of neuronal signaling, a conserved underlying brain architecture and the main classes of neurotransmitter system. Drosophila also have a sophisticated behavioral repertoire that includes extensive abilities to adapt to experience and other circumstances, and is therefore susceptible to the same kinds of insults that can cause neuropsychiatric disorders in humans. Given the different physiologies, lifestyles, and cognitive abilities of flies and humans, many higher order behavioral features of the human disorders cannot be modeled readily in flies. However, an increasing understanding of the genetics of human neuropsychiatric disorders is suggesting parallels with underlying neurobiological mechanisms in flies, thus providing important insights into the possible mechanisms of these poorly understood disorders.