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Yeast artificial chromosomes: tools for mapping and analysis of complex genomes
1Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110.
Trends in Genetics : TIG
|August 1, 1990
Abstract:
Libraries of yeast artificial chromosomes (YACs) are representative of complex genomes, and typical YACs contain single fragments of DNA that are up to a megabase or more in size, are stable during growth, and are faithful to genomic DNA. Such YACs may permit (1) the use of complete gene units for a number of research and medical purposes; and (2) the assembly of chromosome-sized contigs in a single map that unifies genetic and physical data.