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Updated: Jun 5, 2026

Luminophore Formation in Various Conformations of Bovine Serum Albumin by Binding of Gold(III)
Published on: August 31, 2018
Molecular structure-affinity relationship of natural polyphenols for bovine γ-globulin
Jianbo Xiao1, Guoyin Kai, Fan Yang
1Department of Biology, College of Life & Environment Science, Shanghai Normal University, Shanghai, P.R. China. jianboxiao@yahoo.com
Scope:
The aim of this study was to investigate the interaction between polyphenols and bovine γ-globulin.
Methods And Results:
The relationship between the structural properties of natural polyphenols and their affinities for bovine γ-globulin were investigated by fluorescence titration analysis. Methylation of hydroxyl groups on flavonoids weakened the affinities for γ-globulin by 1.20-38.0 times. Hydroxylation on rings A, B, and C of flavonoids also significantly affected the affinity for γ-globulin. Glycosylation of flavonoids slightly affected the affinity depending on the conjugation site and the class of sugar moiety. Hydrogenation of the C2=C3 double bond on flavonoids decreased the binding affinities. Galloylated catechins and catechol-type catechins exhibited higher binding affinities for γ-globulin than non-galloylated and pyrogallol-type catechins. The glycosylation of resveratrol decreased its affinity for γ-globulin.
Conclusion:
The binding process with γ-globulin was strongly influenced by the structural differences of polyphenols.
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