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Related Experiment Video

Updated: Jun 5, 2026

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection

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Published on: March 8, 2017

Systemic side effects of transtympanic steroids.

Ashley B Robey¹, Trish Morrow, Gary F Moore

¹Department of Otolaryngology, Head and Neck Surgery, University of Nebraska, Medical Center, Nebraska, USA.

The Laryngoscope

|January 13, 2011

Summary

Transtympanic steroids offer low systemic and local side effect risks for ear conditions. However, a notable risk of persistent tympanic membrane perforation exists after treatment.

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Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity

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A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection

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Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity

Published on: March 16, 2018

Area of Science:

Otolaryngology
Pharmacology
Medical Devices

Background:

Transtympanic steroid administration is an emerging treatment for various ear conditions.
Understanding the safety profile and efficacy of this delivery method is crucial.

Purpose of the Study:

To review the largest series of patients treated with transtympanic steroids.
To analyze outcomes, steroid dosing, and adverse events.
To report the first cases of systemic side effects from transtympanic steroids.

Main Methods:

Retrospective case series of 166 patients.
Patients underwent transtympanic Silverstein tube placement with microwick for steroid delivery.

Main Results:

Low incidence of systemic (5/166) and local (9/166) side effects.
Significant rate of persistent tympanic membrane perforation (48/166, 29%).
Symptom improvement observed in hearing loss (42%), tinnitus (56%), vertigo (68%), aural fullness (25%), and dysequilibrium (66%).

Conclusions:

Transtympanic steroid administration is associated with a low risk of systemic and local side effects.
A significant risk of persistent tympanic membrane perforation necessitates careful consideration.