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Inflammation01:38

Inflammation

Overview
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Acute Inflammation II: Cellular Phase01:26

Acute Inflammation II: Cellular Phase

The cellular phase of acute inflammation is a tightly orchestrated sequence of events that recruits leukocytes, primarily neutrophils, to sites of tissue injury or infection. Following the initial vascular changes, this phase ensures effective immune cell migration, activation, and function at the affected site to eliminate pathogens and initiate tissue repair.Leukocyte Recruitment CascadeLeukocyte recruitment happens in four steps: margination, adhesion, transmigration, and chemotaxis. Reduced...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

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Related Experiment Video

Updated: Jun 5, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

[Inflammatory process in atherosclerosis].

Ichiro Manabe1

  • 1Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|January 14, 2011
PubMed
Summary
This summary is machine-generated.

Atherosclerosis, a chronic inflammatory disease, involves complex cell interactions. Understanding these molecular mechanisms, particularly bone marrow-derived cells, may reveal new therapeutic targets for atherosclerosis and related metabolic disorders.

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Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis
09:55

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

Published on: October 25, 2024

Related Experiment Videos

Last Updated: Jun 5, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis
09:55

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

Published on: October 25, 2024

Area of Science:

  • Cardiovascular Biology
  • Immunology
  • Metabolic Disease Research

Background:

  • Atherosclerosis is a chronic inflammatory condition.
  • Its development involves intricate interactions between endothelial, smooth muscle, and immune cells.
  • Bone marrow-derived cells, especially immune cells, play significant roles in atherogenesis.

Purpose of the Study:

  • To explore the complex cellular interactions in atherosclerosis.
  • To investigate the role of bone marrow-derived cells in atherogenesis.
  • To understand the link between chronic inflammation and metabolic abnormalities like obesity and diabetes.

Main Methods:

  • Review of recent studies on cellular interactions in atherosclerosis.
  • Analysis of the role of immune cells in atherogenesis.
  • Investigation of molecular mechanisms mediating inflammation in metabolic diseases.

Main Results:

  • Bone marrow-derived cells have critical, previously underestimated roles in atherosclerosis development.
  • Chronic inflammation is intrinsically linked to metabolic issues such as obesity and diabetes.
  • Complex cellular interplays are central to atherogenesis.

Conclusions:

  • Elucidating molecular mechanisms of cellular interactions in chronic inflammation is key.
  • Identifying these mechanisms could lead to novel therapeutic targets for atherosclerosis and metabolic disorders.
  • Further research into immune cell roles in atherogenesis is warranted.