[Anti-atherosclerotic effect of fibrates and eicosapentaenoic acid]
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Updated: Jun 5, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
Yoshiko Sakamoto1, Koichi Node
1Department of Cardiovascular and Renal Medicine, Saga University.
Abstract:
Fibrates and eicosapentaenoic acid (EPA) are effective in lowering elevated plasma triglycerides(TG) and low density lipoprotein cholesterol(LDL-C). These drugs have shown to reduce the risk of major cardiovascular events by several studies. Fibrates activate peroxisome proliferator-activated receptors(PPAR), especially PPARa. EPA and its metabolites act in the body by their interactions with the metabolites of arachidonic acid. Fibrates and EPA have nonlipid peliotropic effects such as anti-inflammation, endothelial-dependent smooth muscle relaxation and anti-thrombus in vascular wall. Thus it is suggested that peliotropic effects of these drugs contribute to the reduction of atherosclerosis progression.
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