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Updated: Jun 5, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
[Study of MDA-LDL by pioglitazone and pitavastatin in patients with type 2 diabetes]
Akihiko Taguchi1, Shunsuke Hayashi
1Department of Hematology and Endocrinology, Shuto General Hospital.
Abstract:
Oxidized LDL accelerates vascular endothelial damage and the progression of early arteriosclerosis, and is known as an independent risk factor for coronary artery disease. In this study, we administered pioglitazone and pitavastatin for 16 weeks to 18 patients who had type 2 diabetes complicated by dyslipidemia and then investigated the influence of these 2 drugs on MDA-LDL(i. e., oxidized LDL). As a result, a significant decrease of MDA-LDL was observed in both groups, but a significant decrease of the MDA-LDL/LDL-C ratio (an indicator of the extent of oxidation of LDL) was only observed in the pioglitazone group. Accordingly, it was demonstrated that pioglitazone improves oxidative stress, and the possibility was suggested that the MDA-LDL/LDL-C ratio is useful for the evaluation of oxidative stress in clinical practice.
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