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[Herpes zoster and its prevention].

Hitoshi Kamiya¹, Yoshizo Asano, Kimiyasu Shiraki

¹National Mie Hospital.

Kansenshogaku Zasshi. the Journal of the Japanese Association for Infectious Diseases

|January 14, 2011

Summary

Herpes zoster is common, affecting one in three before age 80. The Oka varicella vaccine prevents herpes zoster and PHN in the elderly, with a review supporting its introduction in Japan.

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Area of Science:

Virology
Immunology
Epidemiology

Context:

Herpes zoster incidence in Japan is notable, particularly in individuals aged 50 and above.
The Oka varicella vaccine, initially for varicella, is widely used globally.
Previous studies suggest the vaccine boosts immunity against varicella-zoster virus in adults.

Purpose:

To review the link between varicella and the Oka varicella vaccine concerning herpes zoster.
To discuss the findings of Oxman et al. regarding vaccine efficacy in preventing herpes zoster and postherpetic neuralgia (PHN).
To highlight the need for introducing the Oka varicella vaccine for herpes zoster prevention in Japan.

Summary:

Herpes zoster incidence in Japan is 4.15/1,000 person-years, rising to 5.23-7.84/1,000 among those 50+.
The Oka varicella vaccine is proven to prevent herpes zoster and PHN in the elderly, as shown by Oxman et al.
The vaccine is approved for this purpose in the USA and Europe.

Impact:

The Oka varicella vaccine offers a preventative strategy against herpes zoster and PHN for the elderly population.
Introduction of the vaccine in Japan could significantly reduce the burden of herpes zoster.
This review supports the public health initiative of expanding vaccine use to older demographics.