Prenylated flavanones with anti-tyrosinase activity from Dalea boliviana
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Quantification of Hypopigmentation Activity In Vitro
Published on: March 6, 2019
Mariana Andrea Peralta1, María Gabriela Ortega, Alicia Mariel Agnese
1Farmacognosia, Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, 5000 Córdoba, Argentina.
Abstract:
Three new prenylated flavanones, (2S)-5,7,2'-trihydroxy-5'-(1''',1'''-dimethylallyl)-8-prenylflavanone (1), (2S)-5,7,2'-trihydroxy-8,3'-diprenylflavanone (2), and (2S)-5,2'-dihydroxy-6'',6''-dimethylchromeno-(7,8:2'',3'')-3'-prenylflavanone (3), and a known chromeno (dimethylpyrano) flavanone, obovatin (4), were isolated from the n-hexane extract of Dalea boliviana roots. The compounds were evaluated in vitro in relation to their inhibitory effect on the tyrosinase activity by using a spectrophotometric method.
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