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08:02
Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
Published on: February 18, 2015
An interesting entity mimicking malignancy: laryngeal candidiasis
O Saraydaroglu1, H Coskun, B Elezoglu
1Department of Pathology, Uludag University Medical School, Gorukle, Bursa, Turkey. osaraydaroglu@uludag.edu.tr
The Journal of International Medical Research
|January 14, 2011
Summary
Primary laryngeal candidiasis, a rare fungal infection, is linked to immune issues and antibiotic use. This study identified 11 cases, highlighting risk factors like smoking and inhaled corticosteroids.
Area of Science:
- Otolaryngology
- Medical Mycology
- Pathology
Background:
- Primary candidiasis of the laryngeal mucosa is uncommon.
- Predisposing factors include immune insufficiency and prolonged antibiotic therapy.
Purpose of the Study:
- To investigate the clinical and histopathological features of hyperplastic laryngeal candidiasis.
- To identify associated predisposing factors and patient outcomes.
Main Methods:
- Reassessment of 530 laryngeal biopsy specimens from 2004-2009.
- Clinical and histopathological analysis to identify 11 cases of hyperplastic laryngeal candidiasis.
Main Results:
- Identified 11 cases of hyperplastic laryngeal candidiasis.
- Common predisposing factors included smoking (8 cases), inhaled corticosteroids (4 cases), reflux (4 cases), immune insufficiency (3 cases), and long-term antibiotic use (2 cases).
- Two cases showed coexisting dysplasia.
Conclusions:
- Hyperplastic laryngeal candidiasis is associated with several risk factors, notably smoking and inhaled corticosteroid use.
- Surgical intervention is often required, with varied outcomes including recurrence.
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