Related Experiment Video

Updated: Jun 5, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

The molecular biology of prostate cancer morbidity and mortality: Accelerated death from ejaculate poisoning?

E Chou1, J W Simons

  • 1From the Johns Hopkins Oncology Center and the James Buchanan Brady Urological Institute, NIH Special Program of Research Excellence in Prostate Cancer, The Johns Hopkins Hospital, Baltimore, Maryland, USA.

Urologic Oncology
|January 14, 2011
PubMed

Insights

Prostate cancer

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Prostate cancer's molecular biology and host-tumor interactions causing morbidity remain poorly understood.
  • The role of prostate-specific exocrine gene products in advanced prostate cancer symptoms like bone pain and cachexia is unclear.

Purpose of the Study:

  • To explore the poorly understood molecular mechanisms of host-tumor interactions in prostate cancer.
  • To investigate the role of prostate-specific exocrine gene products in mediating cancer morbidity.

Main Methods:

  • Literature review and hypothesis discussion.
  • Analysis of existing evidence on androgen-regulated exocrine gene products.

Main Results:

  • Growing evidence suggests androgen-regulated exocrine gene products may independently drive prostate cancer morbidity.
  • Prostate-specific exocrine genes are implicated in symptoms of advanced disease.

Conclusions:

  • Prostate-specific exocrine genes are hypothesized to be key mediators of prostate cancer patient morbidity.
  • Understanding these genes has significant experimental and clinical implications for managing advanced prostate cancer.

More Related Videos

Phosphopeptide Enrichment Coupled with Label-free Quantitative Mass Spectrometry to Investigate the Phosphoproteome in Prostate Cancer12:23

Phosphopeptide Enrichment Coupled with Label-free Quantitative Mass Spectrometry to Investigate the Phosphoproteome in Prostate Cancer

Published on: August 2, 2018

Generation of a Mouse Prostate Organoid-Based Model for Studying Host-Pathogen Interactions08:05

Generation of a Mouse Prostate Organoid-Based Model for Studying Host-Pathogen Interactions

Published on: February 27, 2026

Related Concept Videos

Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Sperm Transport01:15

Sperm Transport

The journey of sperm from its origin to the point of ejaculation begins within the seminiferous tubules of the testis. Here, Sertoli cells produce fluid that propels non-motile sperm through a series of conduits, starting with the straight tubules leading to the rete testis. This interconnected network of tubules acts as the initial pathway for sperm, guiding them into the efferent ductules and then into the epididymis for maturation.
The maturation phase occurs in the epididymis, where sperm...
Spermatogenesis01:41

Spermatogenesis

Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male reproductive...
Male Sexual Response: Erection & Ejaculation01:17

Male Sexual Response: Erection & Ejaculation

Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...