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Venous giant post-thrombotic chronic ulcer: successful treatment with Bosentan
J V Solís1, J L Portero, L Ribé
1University General Hospital Gregorio Marañón, Calle del Doctor Esquerdo 46, Madrid 28007, Spain. juanv.solis@gmail.com
Objective:
To report a case of a refractory post-thrombotic chronic venous ulcer managed with an off-label treatment.
Method:
We present the case of an 82-year-old woman with a previous medical history of severe hypertension and a deep vein thrombosis three years before. A refractory giant chronic venous ulcer in her left leg was treated with Bosentan.
Results:
The appearance of the ulcer improved in the first 45 days, worsened after an unintended stop of the treatment and was almost resolved after 90 days of treatment. Ulcer-associated pain improved very quickly and so, in only one week, opioid treatment was stopped. Bosentan treatment was well tolerated, with only mild and manageable side effects.
Conclusion:
Treatment with Bosentan has been successful in the treatment of this case of refractory chronic venous ulcer.
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