Related Experiment Video
Updated: Jun 5, 2026
A Gaze-Contingent Display Framework for Perceptual Learning Research with Simulated Central Vision Loss
Published on: April 11, 2025
Wet versus dry age-related macular degeneration in patients with central field loss: different effects on maximum
Aurélie Calabrèse1, Jean-Baptiste Bernard, Louis Hoffart
1Université Aix-Marseille II, CNRS (Centre Nationale de Recherche Scientifique), Institut de Neurosciences Cognitives de Méditerranée, Marseille, France.
Purpose:
To describe new, efficient predictors of maximum reading speed (MRS) in age-related macular degeneration (AMD) patients with central field loss. Type of AMD (wet versus dry) was scrutinized, because this factor seems to offer a promising model of differential visual adaptation induced by different temporal courses of disease progression.
Methods:
Linear mixed-effects (LME) analyses were performed on a dataset initially collected to assess the effect of interline spacing on MRS. MRS was measured with MNread-like French sentences in 89 eyes (64 dry and 25 wet) of 61 patients with AMD. Microperimetry examination was performed on each eye. The eyes were included only if they had a dense macular scotoma including the fovea, to ensure that patients used eccentric viewing.
Results:
Analyses show the unique contributions--after adjustment for the effects of other factors--of three new factors: (1) MRS was higher for wet than for dry AMD eyes; (2) an advantage of similar amplitude was found for phakic eyes compared with pseudophakic eyes; and (3) MRS decreased when distance between fixation preferred retinal locus (PRL) and fovea increased. In addition, the instantaneous slope of the relationship between scotoma area and MRS was much shallower than reported in two other studies.
Conclusions:
The four effects improve the ability to predict MRS reliably for AMD patients. The wet/dry difference is a major finding that may result from the different time courses of the two types of disease, thus involving different types of visuomotor and attentional adaptation processes.
