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Related Concept Videos

Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Mutations01:35

Mutations

Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Mutations01:39

Mutations

Overview
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).

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Updated: Jun 5, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

Double trouble from sunburn: UVB-induced erythema is associated with a transient decrease in skin pigmentation.

F Casetti1, A Miese, M L Mueller

  • 1Department of Dermatology, Competence Center skintegral, University Medical Center Freiburg, Freiburg, Germany.

Skin Pharmacology and Physiology
|January 14, 2011
PubMed
Summary
This summary is machine-generated.

Ultraviolet B (UVB) radiation initially decreases skin pigmentation, making skin more vulnerable to sun damage, despite causing redness. This highlights the need to protect skin from sunburn and adapt gradually to sun exposure.

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Last Updated: Jun 5, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
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Published on: September 7, 2013

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Studying Chronic Exposure of Mice to Ultraviolet B Radiation
03:20

Studying Chronic Exposure of Mice to Ultraviolet B Radiation

Published on: August 19, 2025

Area of Science:

  • Dermatology
  • Photobiology
  • Skin Physiology

Background:

  • Ultraviolet B (UVB) radiation is known to induce inflammatory responses and subsequent skin pigmentation.
  • Simultaneous photometric monitoring of early erythema and pigmentation following UVB exposure has been limited.

Purpose of the Study:

  • To investigate the early time course of erythema and skin pigmentation after Ultraviolet B (UVB) irradiation.
  • To assess the relationship between UVB-induced inflammation and changes in skin pigmentation.

Main Methods:

  • 15 volunteers received controlled UVB irradiation on their forearms.
  • Photometric measurements of erythema and pigmentation were taken at multiple time points (0, 6 hours, 1, 2, 3, and 7 days).
  • Skin biopsies were analyzed using DOPA staining to evaluate melanocyte activity.

Main Results:

  • UVB exposure led to increased skin erythema, peaking at 24 hours and gradually decreasing by day 7.
  • A significant decrease in skin pigmentation was observed in the early stages after UVB exposure.
  • Melanocyte staining confirmed reduced pigmentation, with an increase only observed after 7 days.

Conclusions:

  • Acute UVB-induced erythema is paradoxically linked to a temporary decrease in skin pigmentation, increasing sun damage susceptibility.
  • These findings emphasize the importance of preventing sunburns and gradually acclimating skin to solar radiation.