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Related Experiment Video

Updated: Jun 5, 2026

Dorsal Root Ganglion Injection and Dorsal Root Crush Injury as a Model for Sensory Axon Regeneration
09:48

Dorsal Root Ganglion Injection and Dorsal Root Crush Injury as a Model for Sensory Axon Regeneration

Published on: May 3, 2017

On acute gene expression changes after ventral root replantation.

Marten Risling1, Thomas Ochsman, Thomas Carlstedt

  • 1Department of Neuroscience, Karolinska Institutet Stockholm, Sweden.

Frontiers in Neurology
|January 14, 2011
PubMed
Summary

Spinal ventral root replantation promotes motor axon regrowth and neuron survival. Gene array analysis reveals enhanced neurite growth and synaptic transmission following replantation compared to avulsion alone.

Keywords:
gene expressioninflammationregenerationspinal cordventral root

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Last Updated: Jun 5, 2026

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09:48

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Published on: May 3, 2017

Expansion of Embryonic and Adult Neural Stem Cells by In Utero Electroporation or Viral Stereotaxic Injection
19:45

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Genetic Study of Axon Regeneration with Cultured Adult Dorsal Root Ganglion Neurons
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Genetic Study of Axon Regeneration with Cultured Adult Dorsal Root Ganglion Neurons

Published on: August 17, 2012

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Molecular Biology

Background:

  • Neuronal regeneration in the central nervous system is typically unsuccessful.
  • Spinal ventral root avulsion and replantation present a unique model for studying neuronal repair.
  • Ventral root replantation may rescue motoneurons from death compared to avulsion without repair.

Purpose of the Study:

  • To analyze the acute molecular response to ventral root avulsion and replantation in adult rats.
  • To compare gene expression profiles between ventral root replantation and avulsion-only models.
  • To investigate the neuroregenerative capacity and cellular responses initiated by ventral root replantation.

Main Methods:

  • Adult rats underwent ventral root avulsion or ventral root replantation.
  • Gene arrays were employed to analyze gene expression profiles at 24 hours post-injury.
  • Cluster analysis of gene ontology search terms was used to interpret the data.

Main Results:

  • Significant differences in gene expression were observed between the replantation and avulsion-only groups.
  • While cell death gene numbers were similar, replantation showed more genes related to neurite growth and development.
  • Synaptic transmission gene expression was more pronounced after replantation than after avulsion alone.
  • An acute inflammatory response was noted after avulsion, whereas synaptic effects were greater post-replantation.

Conclusions:

  • Ventral root replantation promotes axonal regeneration and potentially enhances neuron survival.
  • The molecular response indicates that axonal regeneration is initiated earlier in the replantation model.
  • Gene array analysis provides insights into the acute molecular differences between injury and repair models.
  • This approach can facilitate comparative analysis of acute responses in different injury types.