Changes of serum cholinesterase isozyme patterns in liver diseases

A simple method was established for the separation and identification of serum cholinesterase (SChE) isozymes by using gradient polyacrylamide gel electrophoresis and densitometric scanning. With this method, SChE isozyme patterns of 39 healthy adults and 232 patients with liver diseases were studied. 9 to 11 bands of SChE were demonstrated in healthy adults. The activities increasing in Band 1 and decreasing or disappearing in Bands 2, 3, 4 and 5 were found in most patients with liver diseases in comparing with the control. It showed that the activity decreasing is correlated closely with the severity of liver diseases.