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14:04
Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
Published on: May 8, 2013
Risk factors for community-associated methicillin-resistant Staphylococcus aureus cellulitis--and the value of
Thana Khawcharoenporn1, Alan D Tice, Andrew Grandinetti
1John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96813, USA. thanak30@yahoo.com
Hawaii Medical Journal
|January 14, 2011
Summary
Obesity and the presence of abscesses are key risk factors for community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) cellulitis. Identifying these factors can guide appropriate antibiotic selection for MRSA infections.
Area of Science:
- Infectious Diseases
- Dermatology
- Public Health
Background:
- Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is a significant cause of skin and soft tissue infections.
- Cellulitis, a common bacterial skin infection, can be caused by CA-MRSA, necessitating identification of specific risk factors.
Purpose of the Study:
- To determine the independent risk factors associated with CA-MRSA cellulitis.
- To inform clinical decision-making regarding empiric antibiotic therapy for cellulitis.
Main Methods:
- A literature review on CA-MRSA risk factors was conducted.
- A retrospective cohort study analyzed 137 cellulitis cases in an ambulatory-care clinic.
Main Results:
- CA-MRSA was identified in 62% of cellulitis cases, particularly those with abscesses or skin ulcers.
- Obesity (aOR 2.33) and the presence of abscesses (aOR 2.72) were independent risk factors for CA-MRSA cellulitis.
- CA-MRSA patients were less likely to receive appropriate initial antibiotics and more likely to require antibiotic changes.
Conclusions:
- Obesity and the presence of abscesses are significant predictors of CA-MRSA cellulitis.
- Empiric antibiotic treatment for cellulitis should consider these identified risk factors to ensure activity against MRSA.
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