Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Combinatorial Gene Control02:33

Combinatorial Gene Control

Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
Coordination of Gene Expression Processes in Bacteria01:29

Coordination of Gene Expression Processes in Bacteria

The DNA replication, transcription, and translation processes are intricately coupled in bacteria, allowing efficient gene expression and rapid protein synthesis. While this physical and functional coordination is advantageous, it introduces challenges that bacteria overcome through specific regulatory mechanisms.Coupling of Replication, Transcription, and TranslationThe coupling of replication, transcription, and translation is a hallmark of bacterial gene expression. As the replisome unwinds...
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
Operon Model01:23

Operon Model

The operon model represents a fundamental mechanism of gene regulation in prokaryotes, enabling coordinated expression of genes involved in related metabolic or functional pathways. Operons consist of structural genes, a promoter, and an operator, with transcription regulated by repressors, activators, and small effector molecules.Structure and Function of OperonsAn operon is a cluster of structural genes transcribed together under the control of a single promoter. The promoter region...
BIBO stability of continuous and discrete -time systems01:24

BIBO stability of continuous and discrete -time systems

System stability is a fundamental concept in signal processing, often assessed using convolution. For a system to be considered bounded-input bounded-output (BIBO) stable, any bounded input signal must produce a bounded output signal. A bounded input signal is one where the modulus does not exceed a certain constant at any point in time.
To determine the BIBO stability, the convolution integral is utilized when a bounded continuous-time input is applied to a Linear Time-Invariant (LTI) system.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Localized and delocalized modes on random geometric graphs in one dimension.

Physical review. E·2026
Same author

Stochasticity Leads to Coexistence of Generalists and Specialists in Assembling Mutualistic Communities.

The American naturalist·2022
Same author

Master stability functions for metacommunities with two types of habitats.

Physical review. E·2022
Same author

A closed form for Jacobian reconstruction from time series and its application as an early warning signal in network dynamics.

Proceedings. Mathematical, physical, and engineering sciences·2022
Same author

Nested versus Independent Sampling: Solving the Mystery of Contradictory Species-Area Relationships.

The American naturalist·2021
Same author

The concerted emergence of well-known spatial and temporal ecological patterns in an evolutionary food web model in space.

Scientific reports·2021
Same journal

Tension on dsDNA bound to ssDNA-RecA filaments may play an important role in driving efficient and accurate homology recognition and strand exchange.

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
Same journal

Publisher's Note: Amplitude-phase coupling drives chimera states in globally coupled laser networks [Phys. Rev. E 91, 040901(R) (2015)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
Same journal

Erratum: Shapes of sedimenting soft elastic capsules in a viscous fluid [Phys. Rev. E 92, 033003 (2015)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
Same journal

Erratum: Attenuation of excitation decay rate due to collective effect [Phys. Rev. E 90, 022142 (2014)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
Same journal

Publisher's Note: Role of connectivity and fluctuations in the nucleation of calcium waves in cardiac cells [Phys. Rev. E 92, 052715 (2015)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
Same journal

Publisher's Note: Lattice Boltzmann approach for complex nonequilibrium flows [Phys. Rev. E 92, 043308 (2015)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
See all related articles

Related Experiment Video

Updated: Jun 5, 2026

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

Boolean versus continuous dynamics on simple two-gene modules.

Eva Gehrmann1, Barbara Drossel

  • 1Institut für Festkörperphysik, TU Darmstadt, Hochschulstraße 6, 64289 Darmstadt, Germany.

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|January 15, 2011
PubMed
Summary
This summary is machine-generated.

This study explores gene regulatory network dynamics, revealing conditions for stable oscillations in simple two-gene systems. Key factors include time scales, interaction cooperativity, and network logic.

More Related Videos

Continuous Measurement of Biological Noise in Escherichia Coli Using Time-lapse Microscopy
08:25

Continuous Measurement of Biological Noise in Escherichia Coli Using Time-lapse Microscopy

Published on: April 27, 2021

Designing Automated, High-throughput, Continuous Cell Growth Experiments Using eVOLVER
07:26

Designing Automated, High-throughput, Continuous Cell Growth Experiments Using eVOLVER

Published on: May 19, 2019

Related Experiment Videos

Last Updated: Jun 5, 2026

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

Continuous Measurement of Biological Noise in Escherichia Coli Using Time-lapse Microscopy
08:25

Continuous Measurement of Biological Noise in Escherichia Coli Using Time-lapse Microscopy

Published on: April 27, 2021

Designing Automated, High-throughput, Continuous Cell Growth Experiments Using eVOLVER
07:26

Designing Automated, High-throughput, Continuous Cell Growth Experiments Using eVOLVER

Published on: May 19, 2019

Area of Science:

  • Systems biology
  • Computational biology
  • Gene regulatory network analysis

Background:

  • Understanding gene regulatory networks (GRNs) is crucial for deciphering cellular processes.
  • Simple GRN modules provide fundamental insights into complex biological dynamics.
  • Previous studies often analyzed continuous and Boolean models separately.

Purpose of the Study:

  • To investigate the dynamical behavior of simple two-gene regulatory modules.
  • To compare continuous dynamics (mRNA and protein concentrations) with Boolean models of gene activity.
  • To establish general conditions for stable oscillations in these systems.

Main Methods:

  • Utilized a generalized framework to analyze various continuous models and regulatory functions.
  • Compared continuous dynamical systems with Boolean models for gene activity.
  • Analyzed the influence of time scales, cooperativity, and logical structure on system dynamics.

Main Results:

  • Identified conditions for stable oscillations in two-gene GRN modules.
  • Demonstrated that oscillation conditions depend on general features, not specific molecular details.
  • Established that time scales, interaction cooperativity, and logical structure are critical factors.

Conclusions:

  • The findings generalize and unify results from previous disconnected studies.
  • Provides a unified framework for analyzing different continuous models of gene regulation.
  • Highlights the importance of general network properties in determining dynamical outcomes like stable oscillations.