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Updated: Jun 5, 2026

Visualizing Single Molecular Complexes In Vivo Using Advanced Fluorescence Microscopy
Published on: September 8, 2009
Viewing the interior of a single molecule: vibronically resolved photon imaging at submolecular resolution
Chi Chen1, Ping Chu, C A Bobisch
1Department of Physics and Astronomy, University of California, Irvine, California 92697, USA.
Abstract:
We report the spatial imaging of the photon transition probability of a single molecule at submolecular resolution. Photon imaging of a ringlike pattern is further resolved as two orthogonal vibronic transitions after incorporating spectral selectivity. A theoretical model and the calculated intensity images reveal that the transition probability is dominated by the symmetry of the positions of the tip and the transition dipole moment. This imaging technique enables the probing of the electronic and optical properties in the interior of a single molecule.
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