Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of Blood Vessels01:07

Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
Gastrulation01:56

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...
Embryonic Connective Tissues01:20

Embryonic Connective Tissues

During early development, the embryo forms two types of connective tissues— the mesenchyme and mucoid connective tissue.
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development. Mesenchyme is...
Development of the Lymphatic System01:15

Development of the Lymphatic System

The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
Development of the Heart01:27

Development of the Heart

The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Total Anomalous Pulmonary Venous Connections, Human Genetics.

Advances in experimental medicine and biology·2024
Same author

The extent of the raphe in bicuspid aortic valves is associated with aortic regurgitation and aortic root dilatation.

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·2016
Same author

Normal and abnormal development of the aortic wall and valve: correlation with clinical entities.

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·2014
Same author

Development of major aorto-pulmonary collateral arteries in vegf120/120 isoform mouse embryos with tetralogy of fallot.

Pediatric cardiology·2014
Same author

Differential and linear insertion of atrioventricular valves: a useful tool?

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2014
Same author

Expression of Id2 in the second heart field and cardiac defects in Id2 knock-out mice.

Developmental dynamics : an official publication of the American Association of Anatomists·2011

Related Experiment Video

Updated: Jun 5, 2026

En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos
08:57

En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos

Published on: July 27, 2022

Cell origins and tissue boundaries during outflow tract development.

D M Noden1, R E Poelmann, A C Gittenberger-de Groot

  • 1Drew M. Noden is at the Department of Anatomy, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.

Trends in Cardiovascular Medicine
|January 15, 2011
PubMed
Summary

Understanding cardiac outflow tract development requires tracing diverse embryonic cell populations. Identifying their origins and integration is key to preventing congenital heart defects.

More Related Videos

Mucociliary Epithelial Organoids from Xenopus Embryonic Cells: Generation, Culture and High-Resolution Live Imaging
07:44

Mucociliary Epithelial Organoids from Xenopus Embryonic Cells: Generation, Culture and High-Resolution Live Imaging

Published on: July 28, 2020

Studying Wnt Signaling During Patterning of Conducting Airways
13:00

Studying Wnt Signaling During Patterning of Conducting Airways

Published on: October 16, 2016

Related Experiment Videos

Last Updated: Jun 5, 2026

En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos
08:57

En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos

Published on: July 27, 2022

Mucociliary Epithelial Organoids from Xenopus Embryonic Cells: Generation, Culture and High-Resolution Live Imaging
07:44

Mucociliary Epithelial Organoids from Xenopus Embryonic Cells: Generation, Culture and High-Resolution Live Imaging

Published on: July 28, 2020

Studying Wnt Signaling During Patterning of Conducting Airways
13:00

Studying Wnt Signaling During Patterning of Conducting Airways

Published on: October 16, 2016

Area of Science:

  • Developmental biology
  • Cardiovascular embryology
  • Cellular differentiation

Background:

  • Cardiac outflow tract (COFT) and aortic sac morphogenesis involve complex cell migration and differentiation.
  • Multiple embryonic cell populations, including mesodermal and neural crest cells, contribute to COFT structures.
  • Precise contributions and boundaries of these cell types remain incompletely understood.

Purpose of the Study:

  • To define the spatial and temporal contributions of disparate embryonic cell populations to COFT development.
  • To elucidate the cellular origins of endocardium, myocardium, aorticopulmonary septum, and semilunar valves.
  • To provide a foundation for understanding the etiology of outflow tract dysmorphologies.

Main Methods:

  • This study likely involved lineage tracing and cell fate mapping techniques in embryonic models.
  • High-resolution imaging and potentially genetic labeling were employed to track cell movements.
  • Analysis focused on the integration and differentiation of mesodermal and neural crest-derived cells.

Main Results:

  • Mesodermal cells from cranial and paraxial regions form endocardium and myocardium.
  • Neural crest cells contribute significantly to septation and valve formation, though specific roles require further definition.
  • Epicardial and coronary artery precursors also migrate into the developing outflow tract.

Conclusions:

  • Normal heart morphogenesis, particularly of the outflow tract, relies on the coordinated integration of diverse embryonic cell lineages.
  • Clarifying the precise contributions of each cell population is crucial for understanding congenital heart anomalies.
  • This research provides essential insights into the cellular basis of outflow tract development.