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Related Experiment Video

Updated: Jun 5, 2026

Ex Vivo Culture of Pharyngeal Arches to Study Heart and Muscle Progenitors and Their Niche

Ex Vivo Culture of Pharyngeal Arches to Study Heart and Muscle Progenitors and Their Niche

Published on: July 20, 2015

Endoderm and cardiogenesis new insights.

N Nascone¹, M Mercola

¹Department of Cell Biology, Harvard Medical School,Boston, MA 02115,USA.

Trends in Cardiovascular Medicine

|January 15, 2011

Summary

The endoderm plays a crucial role in vertebrate heart development, inducing rhythmic beating and potentially specifying early heart fields. This highlights endodermal signals

Area of Science:

Developmental Biology
Cardiovascular Research
Cell Signaling

Background:

Vertebrate heart development traditionally implicates endoderm in inductive roles.
Endoderm can induce rhythmic beating in presumptive heart mesoderm explants.

Purpose of the Study:

To define discrete phases of cardiogenesis dependent on endodermal signals.
To investigate endoderm's role in specifying the early heart field.

Main Methods:

Utilized heart-specific molecular markers.
Analyzed endodermal inductive capabilities on mesoderm explants.
Assessed endoderm's potential to specify non-cardiac tissues into beating hearts.

Main Results:

Identified distinct cardiogenesis phases requiring endodermal signals for contractility.

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Last Updated: Jun 5, 2026

Ex Vivo Culture of Pharyngeal Arches to Study Heart and Muscle Progenitors and Their Niche

Ex Vivo Culture of Pharyngeal Arches to Study Heart and Muscle Progenitors and Their Niche

Published on: July 20, 2015

En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos

En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos

Published on: July 27, 2022

Imaging Cleared Embryonic and Postnatal Hearts at Single-cell Resolution

Imaging Cleared Embryonic and Postnatal Hearts at Single-cell Resolution

Published on: October 7, 2016

Demonstrated endoderm's capacity to generate beating hearts from non-cardiac tissues.

Provided evidence for endoderm in early heart field specification.

Conclusions:

Endoderm is essential for functional contractility during specific cardiogenesis phases.
Endoderm may initiate the specification of the primary heart field.
Endodermal signaling is a key regulator of heart development.