Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Phase Contrast and Differential Interference Contrast Microscopy01:26

Phase Contrast and Differential Interference Contrast Microscopy

Phase-Contrast Microscopes
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Study on Aroma Formation During the Withering Period of Ningchow Black Tea.

Foods (Basel, Switzerland)·2026
Same author

Hypoxia-preconditioned adipose-derived stem cells with injectable small intestinal submucosa for enhanced cartilage repair in osteoarthritis.

Bioengineering & translational medicine·2026
Same author

Interpretable deep learning-based hierarchical multi-modal fusion model for predicting HER2 expression in gastric cancer.

Frontiers in oncology·2026
Same author

Validating the accuracy of Omron HEM-790XT1 electronic blood pressure monitor in the general population according to AAMI/ESH/ISO (ISO 81060-2:2018 + AMD1:2020).

Blood pressure·2026
Same author

Gut microbiota-derived trimethylamine-N-oxide protects pulmonary vascular barrier integrity via Vav guanine nucleotide exchange factor 3 (VAV3)-mediated cytoskeletal remodelling in acute lung injury.

British journal of pharmacology·2026
Same author

An Efficient Strategy to Separate the Main Ginsenosides From Steamed Panax quinquefolius by a Combination of Consecutive and Online-Storage Inner-Recycling High-Speed Counter-Current Chromatography.

Journal of separation science·2026

Related Experiment Video

Updated: Jun 5, 2026

Transcutaneous Microcirculatory Imaging in Preterm Neonates
06:27

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

Phase contrast imaging in neonates.

Kai Zhong1, Thomas Ernst, Steve Buchthal

  • 1Department of Biomedical Magnetic Resonance, Faculty for Natural Sciences, Otto-von-Guericke University Magdeburg, Leipziger Strasse 44, Haus 65, D-39120, Magdeburg, Germany. kai.zhong@nat.uni-magdeburg.de

Neuroimage
|January 15, 2011
PubMed
Summary
This summary is machine-generated.

Magnetic resonance phase imaging reveals differences in neonatal brains compared to adults. This technique offers a new way to study infant brain development and diseases.

More Related Videos

State of the Art Cranial Ultrasound Imaging in Neonates
10:02

State of the Art Cranial Ultrasound Imaging in Neonates

Published on: February 2, 2015

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography
09:31

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography

Published on: January 27, 2023

Related Experiment Videos

Last Updated: Jun 5, 2026

Transcutaneous Microcirculatory Imaging in Preterm Neonates
06:27

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

State of the Art Cranial Ultrasound Imaging in Neonates
10:02

State of the Art Cranial Ultrasound Imaging in Neonates

Published on: February 2, 2015

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography
09:31

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography

Published on: January 27, 2023

Area of Science:

  • Neuroimaging
  • Biophysics
  • Developmental Neuroscience

Background:

  • Magnetic resonance (MR) phase imaging offers enhanced contrast between gray and white matter compared to magnitude imaging.
  • Contrast mechanisms in MR phase imaging are not fully understood, with prior research limited to adult subjects.
  • Neonatal brain development involves significant changes in myelination and iron deposition.

Purpose of the Study:

  • To demonstrate magnetic resonance phase imaging in the neonatal brain for the first time.
  • To investigate the differences in phase contrast between neonatal and adult brains.
  • To explore the potential of MR phase imaging for studying neonatal brain development and pathologies.

Main Methods:

  • Acquisition of MR phase images in neonatal subjects.
  • Comparison of phase differences between gray and white matter in neonates versus adults.
  • Analysis of potential factors contributing to observed phase differences, such as macromolecule concentration and myelination.

Main Results:

  • Phase differences between gray and white matter are significantly reduced in neonates compared to adults.
  • Observed phase differences in neonates are not inverted, correlating with lower myelination and iron content.
  • A potential contribution of macromolecule concentration and water-macromolecule exchange to neonatal phase differences is proposed.

Conclusions:

  • MR phase imaging is feasible and provides valuable insights into the neonatal brain.
  • Reduced phase contrast in neonates is linked to developmental factors like myelination.
  • MR phase imaging is a promising novel tool for studying neonatal brain development and identifying pathologies.