Related Experiment Video
Updated: Jun 5, 2026

09:09
In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
The Atlas of Physiology and Pathophysiology: Web-based multimedia enabled interactive simulations
Jiri Kofranek1, Stanislav Matousek, Jan Rusz
1Charles University in Prague, First Faculty of Medicine, Department of Pathological Physiology, U nemocnice 5, 128 53 Praha 2, Czech Republic. kofranek@gmail.com
Computer Methods and Programs in Biomedicine
|January 15, 2011
Summary
The Atlas of Physiology and Pathophysiology (Atlas) is a new interactive tool for biomedical education. It combines simulations and tutorials to explain physiological systems and their disorders.
Area of Science:
- Biomedical Education
- Physiology
- Pathophysiology
Background:
- Traditional biomedical education often lacks interactive and engaging tools.
- There is a need for accessible resources that explain complex physiological systems and disorders.
Purpose of the Study:
- To present the development status of the Atlas of Physiology and Pathophysiology (Atlas).
- To introduce a novel interactive multimedia application for biomedical education.
- To combine simulations with tutorials in a user-friendly interface.
Main Methods:
- Developed component-based tools for creating simulation models.
- Created interactive multimedia elements.
- Integrated simulations, tutorials, and underlying complex models into a unified application.
- Required interdisciplinary collaboration among educators, analysts, artists, and programmers.
Main Results:
- The Atlas is a freely available online application.
- It simplifies the presentation layer while retaining model complexity.
- Tools were developed for component-based simulation model creation and multimedia integration.
Conclusions:
- The Atlas offers a valuable resource for understanding physiological systems and their disorders.
- The developed tools facilitate the creation of complex, interactive educational applications.
- The application enhances biomedical education through engaging multimedia and simulations.
Related Concept Videos
Overview of Anatomy and Physiology
Human anatomy is the scientific study of the body's structures. Some of these structures are very small and can only be observed and analyzed with the assistance of a microscope. Other larger structures can readily be seen, manipulated, measured, and weighed. The word "anatomy" comes from a Greek root that means "to cut apart." Human anatomy was first studied by observing the body's exterior and the wounds of soldiers and other injuries. Later, physicians were allowed to dissect the bodies of...
Anatomy of the Circulatory System
The human circulatory system consists of blood, blood vessels that carry blood away from the heart, around the body, and back to the heart, and the heart itself, which acts as a central pump. The systemic circuit supplies blood to the whole body, the coronary circuit supplies blood to the heart, and the pulmonary circuit supplies blood flow between the heart and lungs.
Anatomy of the Heart
The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
Skeletal Muscle Anatomy
Skeletal muscle is the most abundant type of muscle in the body. Tendons are the connective tissue that attaches skeletal muscle to bones. Skeletal muscles pull on tendons, which in turn pull on bones to carry out voluntary movements.
Gross Anatomy of the Lungs
The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
Positron Emission Tomography
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...

