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Dynamin binding protein gene expression and memory performance in aged rats.

Tiziana Casoli1, Giuseppina Di Stefano, Patrizia Fattoretti

  • 1Neurobiology of Aging Laboratory, INRCA Scientific Technological Area, Ancona, Italy. t.casoli@inrca.it

Neurobiology of Aging
|January 15, 2011
PubMed
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Physiological aging reduces dynamin-binding protein (DNMBP) mRNA in rat hippocampi. Preserving long term memory formation during aging may require the ability to increase DNMBP mRNA expression.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Aging Research

Background:

  • Dynamin-binding protein (DNMBP) is a scaffold protein involved in actin cytoskeleton and synaptic vesicle regulation.
  • Previous research indicated lower DNMBP mRNA levels in Alzheimer's disease brains.
  • Aging is associated with cognitive decline, including deficits in long term memory formation.

Purpose of the Study:

  • To investigate the association between physiological aging, long term memory formation, and hippocampal DNMBP mRNA expression.
  • To determine if reduced DNMBP expression correlates with memory impairment in aging rats.

Main Methods:

  • Quantification of hippocampal DNMBP mRNA using quantitative real time reverse transcriptase polymerase chain reaction (qRT-PCR).
  • Inhibitory avoidance task was used to assess long term memory performance in rats.

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  • Animals were categorized into adult, late-adult, and aged groups, with aged rats further classified as good responders (GR) and bad responders (BR) based on memory performance.

    • Main Results:

    • DNMBP mRNA levels were significantly decreased in naive aged rats compared to naive adult rats.
    • Aged rats with better memory performance (GR) exhibited higher DNMBP mRNA levels than poor responders (BR).
    • DNMBP mRNA levels were lower in both GR and BR groups compared to aged-matched controls.

    Conclusions:

    • Hippocampal DNMBP mRNA expression is reduced during physiological aging.
    • The ability to upregulate DNMBP mRNA expression may be crucial for maintaining long term memory during aging.
    • DNMBP may play a significant role in age-related memory decline.