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Single-Cell RNA Sequencing of Mutant Whole Mouse Embryos: From the Epiblast to the End of Gastrulation
09:14

Single-Cell RNA Sequencing of Mutant Whole Mouse Embryos: From the Epiblast to the End of Gastrulation

Published on: June 14, 2024

Early embryonic lethality in genetically engineered mice: diagnosis and phenotypic analysis

V E Papaioannou1, R R Behringer

  • 1Department of Genetics and Development, Columbia University Medical Center, 701 W 168th St, New York, NY 10032, USA. vep1@columbia.edu

Veterinary Pathology
|January 15, 2011
PubMed

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Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...