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Related Experiment Video

Updated: Jun 5, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Scleroderma: the need for extreme remedies.

Nancy J Olsen¹

¹Division of Rheumatic Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA. nolsen@hmc.psu.edu

The American Journal of the Medical Sciences

|January 15, 2011

Summary

Scleroderma, a complex autoimmune disorder, presents significant challenges. Advances in managing renal crisis have improved outcomes, but pulmonary complications remain a major concern.

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Last Updated: Jun 5, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Area of Science:

Rheumatology
Immunology
Vascular Biology

Background:

Scleroderma is a multisystem autoimmune disorder with unknown etiology.
Pathogenesis involves autoimmune responses, vascular abnormalities, and connective tissue accumulation.
Clinical management remains challenging, with significant premature mortality.

Observation:

Advances in managing scleroderma renal crisis have reduced renal failure prevalence.
Glucocorticoid avoidance and early angiotensin system blockade are key strategies.
Pulmonary complications, including interstitial fibrosis and pulmonary hypertension, are now primary causes of morbidity and mortality.

Findings:

Recent studies explore immune suppression interventions for scleroderma.
These interventions may reduce the fibrotic burden in affected organs.
Potential exists to halt or even reverse some organ damage in scleroderma.

Implications:

Improved management strategies for scleroderma renal crisis have been established.
Pulmonary manifestations are now a critical focus for scleroderma research and treatment.
Targeting immune activity offers potential therapeutic avenues for halting or reversing scleroderma-related organ damage.