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Related Experiment Video

Updated: Jun 5, 2026

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Aging changes of vitreomacular interface.

Hirotaka Itakura¹, Shoji Kishi

¹Department of Ophthalmology, Gunma University School of Medicine, Maebashi, Japan. itakurah@med.gunma-u.ac.jp

Retina (Philadelphia, Pa.)

|January 15, 2011

Summary

This summary is machine-generated.

The posterior precortical vitreous pocket is common in normal eyes. Spectral-domain optical coherence tomography reveals age-related changes like thickened vitreous cortex and posterior vitreous detachment.

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Area of Science:

Ophthalmology
Anatomy
Imaging Techniques

Background:

The posterior precortical vitreous pocket is a premacular liquefied lacuna.
Its physiologic presence has been documented in autopsy studies.

Purpose of the Study:

To describe the morphologic features of the posterior precortical vitreous pocket in normal individuals.
To investigate age-related changes in the vitreous cortex.

Main Methods:

Spectral-domain optical coherence tomography (SD-OCT) was used.
102 eyes from 51 normal subjects of varying ages were examined in a sitting position.

Main Results:

The pocket was identified in 83.3% of eyes.
Vitreous cortex thinned centrally and thickened peripherally with age.
Posterior vitreous detachment and lamellar structure of the vitreous cortex were observed in older subjects (>51 years).

Conclusions:

SD-OCT confirmed the pocket's presence across all age groups.
Thickened vitreous cortex and perifoveal posterior vitreous detachment are physiologic in older individuals.
Lamellar structure may indicate vitreoschisis.