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Published on: July 25, 2019

Right atrial myxoma with glandular differentiation: A rare entity in pediatric age group

Saumya R Mallick1, Prasenjit Das, Bhaskar Shukla

  • 1Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Annals of Pediatric Cardiology
|January 15, 2011
PubMed

Insights

This study reports a rare cardiac myxoma (CM) with glandular differentiation in a child. Recognizing this rare pediatric presentation is crucial to avoid misdiagnosis as adenocarcinoma.

Area of Science:

  • Cardiovascular Pathology
  • Pediatric Oncology

Background:

  • Cardiac myxomas (CMs) are the most common primary cardiac tumors, typically affecting the elderly.
  • These tumors originate from sub-endocardial cells with potential for divergent differentiation.

Observation:

  • A 10-year-old child presented with exertional respiratory distress due to two large right atrial masses.
  • Echocardiography revealed interconnected masses measuring up to 34x30 mm.

Findings:

  • Microscopic examination confirmed a cardiac myxoma with prominent glandular differentiation.
  • The tumor exhibited a characteristic immunophenotype, distinct from metastatic adenocarcinoma.

Implications:

  • This case highlights the rare occurrence of cardiac myxoma with glandular differentiation in pediatric patients.
  • Accurate histomorphologic recognition is essential to differentiate from malignant tumors like adenocarcinoma.

Keywords:
Cardiac myxomachildrendivergentglandular differentiationlepidic cells

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