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Updated: Jun 5, 2026
A New Method for Inducing a Depression-Like Behavior in Rats
Published on: February 22, 2018
Experimental model of combined pain and depression status in rats
N A Krupina1, N N Khlebnikova, I N Orlova
1Laboratory of Nervous System General Pathology, Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia. krupinana@yandex.ru
Abstract:
Combined pain and depression status in rats was created by inducing experimental depressive syndrome (by subchronic injection of MPTP proneurotoxin) in animals with manifest and developing neurogenic pain syndrome induced by preliminary crossing of the sciatic nerve in the hind limb. The neurogenic pain syndrome augmented by some parameters the depressive symptoms and provoked manifestation of signs of depressive behavior in animals treated with saline.
