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Related Experiment Video

Updated: Jun 5, 2026

Selective Harvesting of Marginating-pulmonary Leukocytes

Selective Harvesting of Marginating-pulmonary Leukocytes

Published on: March 11, 2016

Size-selective sampling of particulates using a physiologic sampling pump.

Larry A Lee¹, Eun Gyung Lee, Taekhee Lee

¹National Institute for Occupational Safety and Health (NIOSH), Health Effects Laboratory Division (HELD), Morgantown, WV 26505-2888, USA.

Journal of Environmental Monitoring : JEM

|January 15, 2011

Summary

This summary is machine-generated.

Physiologic sampling pumps (PSPs) were modified for size-selective particulate sampling. This new method enables accurate collection of respirable particulates proportional to inhalation rate.

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Area of Science:

Occupational Health
Environmental Science
Aerosol Science

Background:

Traditional personal exposure monitoring methods may not accurately represent gas, vapor, and particulate inhalation.
Physiologic sampling pumps (PSPs) previously adapted for gas/vapor sampling require modification for particulate analysis.

Purpose of the Study:

To modify a physiologic sampling pump (PSP) for size-selective particulate sampling.
To evaluate the performance of a modified PSP for collecting respirable particulates proportional to inhalation.

Main Methods:

A modified PSP design utilizes a cyclone and valves to control airflow through a sampling filter based on physiologic inputs.
Monodisperse ammonium fluorescein aerosols of varying sizes were used to test the prototype under simulated inhalation rates (9 duty cycles).
Particle collection efficiency was evaluated by bias mapping against a standard respirable convention.

Main Results:

The modified PSP demonstrated favorable performance, with the cyclone matching commercial models operating at constant airflow.
The system accurately collected respirable particulates proportional to inhalation rate across various simulated breathing patterns.
Efficiency curves showed good agreement with established respirable conventions for the size distributions tested.

Conclusions:

The modified physiologic sampling pump (PSP) is a feasible method for accurate, size-selective sampling of respirable particulates.
This advancement improves personal exposure assessment by enabling physiologically proportional particulate monitoring.
The technology offers a more representative estimation of personal exposure to airborne particulates.