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Updated: Jun 5, 2026
Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model
Published on: May 21, 2013
The treatment of chondral and osteochondral defects of the knee with autologous matrix-induced chondrogenesis (AMIC):
Jan Philipp Benthien1, Peter Behrens
1Department of Orthopaedic Surgery, University of Basel, Basel, Switzerland, jbenthien@uhbs.ch
Purpose:
Articular resurfacing by treatment of chondral defects may include chondral abrasion, autologous chondrocyte Implantation (ACI), matrix-induced chondrocyte transplantation (MACT) or osteochondral autologous transplantation (OATS). This technical note describes the method of autologous matrix-induced chondrogenesis (AMIC), a one-step procedure combining subchondral microfracture with the fixation of a collagen I/III membrane with fibrin glue or sutures.
Methods:
This is a technical note on the AMIC procedure and its further development.
Results And Conclusion:
This method is applied primarily in chondral or osteochondral lesions of the knee. Indications and contraindications are provided; the technique is described. The further development of AMIC is described with an increased focus on the subchondral zone and the complex of cartilage and bone, the osteochondral unit, which receives increased attention in cartilage research.
Level Of Evidence:
IV.
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