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Updated: Jun 5, 2026

A Method to Preserve Wetland Roots and Rhizospheres for Elemental Imaging
Published on: February 15, 2021
Chemical studies on the roots of Uvaria welwitschii
Masataka Moriyasu1, Noriyoshi Nakatani, Momoyo Ichimaru
1Department of Natural Medicinal Chemistry, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan. moriyasu@kobepharma-u.ac.jp
Abstract:
A chemical investigation of the chloroform extract of the roots of Uvaria welwitschii (Annonaceae), an African traditional medicine taken for stomach ache, led to the isolation of eight new compounds, named welwitschins A-H (1-8), together with five known compounds (9-13). The structural elucidation by spectroscopic studies of the compounds isolated is described. All new compounds were flavonoids having a 2-hydroxy-3,4,6-trimethoxyphenyl moiety in the A-ring, and unsubstituted phenyl in the B-ring. Four of them (1-4) were monomeric flavonoids while the others (5-8) were dimeric flavonoids. The cytotoxicity of the isolated compounds against human promyelocytic leukemia HL-60 cells was investigated.
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