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Published on: May 24, 2021
Ghrelin and Ang 1-7 have cumulative vasodilatory effects on pulmonary vessels
Maria Dincă1, Irina Luciana Dumitriu, Mihaela Beatrice Gurzu
1Functional Sciences Department, School of Medicine, Gr.T. Popa University of Medicine and Pharmacy Iaşi.
Unlabelled:
Ghrelin is an orexigenic hormone that has been shown to have vasodilator effects. Angiotensin 1-7 (Ang 1-7) is a bioactive component of the renin-angiotensin system and may play an important role in the regulation of cardiovascular homeostasis.
Aim:
The aim of this study was to investigate the interaction between ghrelin and a better known vasodilatator, Ang 1-7.
Material And Method:
The dose-dependent relaxing effects of ghrelin were assessed on pulmonary artery rings of male Wistar rats with intact endothelium in the absence or the presence of Ang 1-7. Ang 1-7 was added in the organ bath with 5 minutes before N(G)-nitro L-arginine methyl ester (L-NAME, 1 micro/M) and indomethacin administration in the presence of cumulative doses of ghrelin.
Results:
Our results showed that Ang 1-7 could improve and restore vasorelaxant effects of ghrelin on rat pulmonary rings with intact endothelium.
Conclusion:
Vasodilatatory actions of ghrelin are potentiated by Ang 1-7 and mediated by local synthesis of prostaglandins and nitric oxide.
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