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Proton pump inhibitors in pediatrics: evaluation of efficacy in GERD therapy

Claudio Romano1, Andrea Chiaro, Donatella Comito

  • 1Pediatric Department, University of Messina, Italy. romanoc@unime.it

Current Clinical Pharmacology
|January 18, 2011
PubMed

Insights

Gastroesophageal reflux (GER) is common in infants and usually resolves with supportive care. Proton Pump Inhibitors (PPIs) effectively treat GER disease (GERD) in children, but their use requires careful consideration of indications and safety.

Area of Science:

  • Pediatric Gastroenterology
  • Pharmacology

Background:

  • Gastroesophageal reflux (GER) is a physiological process in infants.
  • GER disease (GERD) involves troublesome symptoms or complications requiring intervention.
  • Proton Pump Inhibitors (PPIs) are effective for pediatric GERD.

Purpose of the Study:

  • To review the appropriate use of PPIs in pediatric GERD.
  • To outline indications, dosages, treatment duration, and safety of PPIs in children.

Main Methods:

  • Literature review on PPIs for pediatric GERD.
  • Analysis of current clinical practices and evidence.

Main Results:

  • PPIs like omeprazole, lansoprazole, and esomeprazole are available for infants.
  • Empirical PPI use for nonspecific infant symptoms is common but lacks randomized controlled studies.

Conclusions:

  • Guidelines for correct PPI indications, dosages, and duration are needed for pediatric GERD.
  • Ensuring the safe and effective use of PPIs in the pediatric population is crucial.

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