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Related Concept Videos

Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence01:19

Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence

Pharmaceutical products contain more than just the active drug; they also contain various excipients such as binders, solubilizers, stabilizers, preservatives, and other elements. In some cases, impurities or contaminants might be present. Traditionally, quality control in pharmaceuticals has primarily focused on the analysis of the active drug, often overlooking the impact of these additional components. The recent issue with heparin contamination by over-sulfated chondroitin sulfate, a...
Modified-Release Drug Delivery Systems: Overview01:19

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Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
Drug Delivery Systems: Different Types01:27

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Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
Oral Drug Delivery Systems: Introduction01:23

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Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.

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Direct compression high functionality excipient using coprocessing technique: a brief review.

A G Mirani1, S P Patankar, V S Borole

  • 1Department of Pharmaceutics, Bharati Vidyapeeth's college of Pharmacy, CBD Belapur, Sector-8, Navi-Mumbai-400614, India.

Current Drug Delivery
|January 18, 2011
PubMed
Summary

Coprocessing active pharmaceutical ingredients (APIs) creates high-functional excipients for direct compression tablet manufacturing. This cost-effective method improves API properties and overcomes limitations in tablet production.

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Chemical Engineering

Background:

  • Tablets are a preferred dosage form due to manufacturing ease, administration convenience, accurate dosing, and stability.
  • Direct compression is an ideal tablet manufacturing method, but less than 20% of active pharmaceutical ingredients (APIs) possess suitable properties for this process.
  • The growing trend towards direct compression necessitates the development of high-functionality excipients.

Purpose of the Study:

  • To review the advantages and applications of coprocessed excipients in pharmaceutical formulations.
  • To explore the role of material science principles in the coprocessing of excipients.
  • To discuss various coprocessing methods and the properties of commercially available coprocessed excipients.

Main Methods:

  • Particle engineering through coprocessing of existing excipients.
  • Combining two or more excipients to achieve synergistic effects at a sub-particle level.
  • Analysis of material science contributions to excipient functionality.

Main Results:

  • Coprocessing enhances excipient functionality, improving properties like flow, cohesion, and lubrication.
  • This technique can mask undesirable API properties, enabling direct compression for a wider range of substances.
  • Coprocessing is a cost-effective strategy for developing advanced pharmaceutical excipients.

Conclusions:

  • Coprocessed excipients offer significant advantages for direct compression tablet manufacturing.
  • Material science plays a crucial role in designing and optimizing coprocessed excipients.
  • Further development and utilization of coprocessed excipients are essential for advancing tablet technology.