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Vitamin E and all-cause mortality: a meta-analysis.
Erin L Abner1, Frederick A Schmitt, Marta S Mendiondo
1Sanders-Brown Center on Aging, University of Kentucky, KY 40536, USA. elabne0@email.uky.edu
Current Aging Science
|January 18, 2011
Summary
Supplemental vitamin E (alpha-tocopherol) shows no effect on all-cause mortality in adults. This meta-analysis of 57 trials found no link between vitamin E dose and mortality risk.
Area of Science:
- Nutrition Science
- Clinical Trials
- Meta-Analysis
Background:
- Vitamin E (alpha-tocopherol) is an antioxidant studied for its potential health benefits.
- Previous research has explored the relationship between vitamin E supplementation and mortality.
- The impact of long-term vitamin E supplementation on all-cause mortality requires reexamination.
Purpose of the Study:
- To re-evaluate the association between vitamin E supplementation and all-cause mortality.
- To synthesize data from randomized controlled trials investigating vitamin E's effect on mortality.
- To determine if vitamin E dose influences mortality risk.
Main Methods:
- Systematic search of MEDLINE, Cochrane Library, and Biological Abstracts databases for relevant trials.
- Inclusion of randomized controlled trials with a minimum one-year supplementation period in adults.
- Meta-analysis of mortality data from 57 trials, encompassing 246,371 subjects and 29,295 deaths.
Main Results:
- The pooled risk ratio for all-cause mortality was 1.00 (95% CI: 0.98, 1.02), indicating no significant effect.
- No relationship was found between the dose of vitamin E supplementation and the risk of mortality.
- The analysis included trials with supplementation durations ranging from one to 10.1 years.
Conclusions:
- Supplementation with vitamin E does not appear to affect all-cause mortality in adults.
- The findings suggest that vitamin E supplementation is safe concerning mortality risk, even at high doses (up to 5,500 IU/d).
- Further research may explore specific health outcomes beyond mortality.
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